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38194-50-2 - Sulindac - cis-5-Fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]indene-3-acetic acid - MK-231 - J61772 - Alfa Aesar

J61772 Sulindac

CAS Number
38194-50-2
Synonyms
cis-5-Fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]indene-3-acetic acid
MK-231

Size Price ($) Quantity Availability
5g 48.60
25g 194.00
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Sulindac

MDL
MFCD00599589
EINECS
253-819-2

Chemical Properties

Formula
C20H17FO3S
Formula Weight
356.41
Form
Powder
Melting point
182-185°
Solubility
Soluble in water, methanol, ethanol.

Applications

Sulindac inhibits the NF-κB pathway. Sulindac is a non-steroidal anti-inflammatory drug. Sulindac reduces the level and activity of several cyclin-dependent kinases and induces apoptosis. It is an antitumor agent. Sulindac is an inhibitor of Cox-1 and Cox-2.

Notes

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

William R. Waddell.; Gary F. Ganser.; Elmo J. Cerise.; Richard W. Loughry. Sulindac for polyposis of the colon. The American Journal of Surgery. 1989, 157, (1), 175-179.

William R. Waddell.; Richard W. Loughry. Sulindac for polyposis of the colon. Journal of Surgical Oncology. 1983, 24, (1), 83-87.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H317-H334-H361

Toxic if swallowed. May cause an allergic skin reaction. May cause allergy or asthma symptoms or breathing difficulties if inhaled. Suspected of damaging fertility or the unborn child.

Precautionary Statements: P285-P201-P261-P280-P281-P301+P310-P342+P311-P363-P405-P501a

In case of inadequate ventilation wear respiratory protection. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,8982
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2930.90
TSCA
No
RTECS
NK8226000

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