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Sulindac inhibits the NF-κB pathway. Sulindac is a non-steroidal anti-inflammatory drug. Sulindac reduces the level and activity of several cyclin-dependent kinases and induces apoptosis. It is an antitumor agent. Sulindac is an inhibitor of Cox-1 and Cox-2.
William R. Waddell.; Gary F. Ganser.; Elmo J. Cerise.; Richard W. Loughry. Sulindac for polyposis of the colon. The American Journal of Surgery. 1989, 157, (1), 175-179.
William R. Waddell.; Richard W. Loughry. Sulindac for polyposis of the colon. Journal of Surgical Oncology. 1983, 24, (1), 83-87.
Hazard Statements: H301-H317-H334-H361
Toxic if swallowed. May cause an allergic skin reaction. May cause allergy or asthma symptoms or breathing difficulties if inhaled. Suspected of damaging fertility or the unborn child.
Precautionary Statements: P201-P202-P261-P264b-P270-P272-P280g-P281-P285-P301+P310-P302+P352-P304+P341-P308+P313-P330-P333+P313-P342+P311-P363-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves. Use personal protective equipment as required. In case of inadequate ventilation wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. IF exposed or concerned: Get medical advice/attention. Rinse mouth. If skin irritation or rash occurs: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant