Sulindac inhibits the NF-κB pathway. Sulindac is a non-steroidal anti-inflammatory drug. Sulindac reduces the level and activity of several cyclin-dependent kinases and induces apoptosis. It is an antitumor agent. Sulindac is an inhibitor of Cox-1 and Cox-2.
William R. Waddell.; Gary F. Ganser.; Elmo J. Cerise.; Richard W. Loughry. Sulindac for polyposis of the colon. The American Journal of Surgery. 1989, 157, (1), 175-179.
William R. Waddell.; Richard W. Loughry. Sulindac for polyposis of the colon. Journal of Surgical Oncology. 1983, 24, (1), 83-87.
Hazard Statements: H301-H334-H317-H361
Toxic if swallowed. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. Suspected of damaging fertility or the unborn child.
Precautionary Statements: P284-P201-P261-P301+P310a-P405-P501a
Wear respiratory protection. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. IF SWALLOWED: Immediately call a POISON CENTER/doctor Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.