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56-25-7 - Cantharidin, 98% - J61801 - Alfa Aesar

J61801 Cantharidin, 98%

CAS Number
56-25-7
Synonyms

Size Price ($) Quantity Availability
100mg 183.00
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Cantharidin, 98%

MDL
MFCD00134968
EINECS
200-263-3

Chemical Properties

Formula
C10H12O4
Formula Weight
196.20
Form
Powder
Melting point
215-217°
Solubility
Soluble in DMSO (25 mg/ml warm), acetone (8 mg/ml), ethanol (8 mg/ml warm), chloroform (1:65), ether (1:560), and ethyl acetate (1:150).

Applications

Cantharidin is used as a potent inhibitor of PP2A phosphatase activity. It has been shown to stimulate cell cycle progression and induce premature mitosis, used topically (0.7%) as an anti-wart treatment, and has been shown to be active in cervical, tongue, neuroblastoma, bone, leukemia, ovarian, colon, and various other cancer cell lines.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents.

Literature References

T I Baskin; J E Wilson. Inhibitors of protein kinases and phosphatases alter root morphology and disorganize cortical microtubules. Plant Physiology.1997, 113 , (2), 493-502.

McCluskey A.; Sim A.T.R.; and Sakoff J.A. Serine-threonine protein phosphatase inhibitors: Development of potential therapeutic strategies. J Med Chem.2002, 45 , (6), 1151-1175.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H315-H319-H335

Fatal if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280a-P301+P310a-P305+P351+P338-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF SWALLOWED: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,1752
Hazard Class
6.1
Packing Group
I
Harmonized Tariff Code
2918.99
TSCA
Yes
RTECS
RN8575000

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