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Cantharidin is used as a potent inhibitor of PP2A phosphatase activity. It has been shown to stimulate cell cycle progression and induce premature mitosis, used topically (0.7%) as an anti-wart treatment, and has been shown to be active in cervical, tongue, neuroblastoma, bone, leukemia, ovarian, colon, and various other cancer cell lines.
T I Baskin; J E Wilson. Inhibitors of protein kinases and phosphatases alter root morphology and disorganize cortical microtubules. Plant Physiology.1997, 113 , (2), 493-502.
McCluskey A.; Sim A.T.R.; and Sakoff J.A. Serine-threonine protein phosphatase inhibitors: Development of potential therapeutic strategies. J Med Chem.2002, 45 , (6), 1151-1175.
Hazard Statements: H300-H315-H319-H335
Fatal if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P301+P310a-P305+P351+P338-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.