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2398-96-1 - Tolnaftate - Methyl-(3-methylphenyl)carbamothioic acid O-2-naphthyl ester - Carbamothioic acid - J61834 - Alfa Aesar

J61834 Tolnaftate

CAS Number
2398-96-1
Synonyms
Methyl-(3-methylphenyl)carbamothioic acid O-2-naphthyl ester
Carbamothioic acid

Size Price ($) Quantity Availability
1g 45.80
5g 149.00
25g 481.00
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Tolnaftate

MDL
MFCD00056611
EINECS
219-266-6

Chemical Properties

Formula
C19H17NOS
Formula Weight
307.41
Form
Powder
Melting point
110-113°
Solubility
Soluble in chloroform at 50 mg/ml. Sparingly soluble in ethanol or methanol

Applications

Tolnaftate is used to study the mechanism of ergosterol (sterol) biosynthesis at the rate-limiting step of squalene epoxidase inhibition. Tolnaftate is clinically used to treat cutaneous infections such as athlete?s foot, jock itch, and ringworm1. It also has been used as a comparator compound for antifungal efficiency studies.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C

Literature References

Craig Knox et. al. DrugBank 3.0: a comprehensive resource for omics research on drugs. Nucleic Acids Research. 2011, 39, D1035-D1041.

J Pannu et. al. NB-002, a novel nanoemulsion with broad antifungal activity against dermatophytes, other filamentous fungi, and Candida albicans. Antimicrobial Agents and Chemotherapy. 2011, 53, (8), 3273-3279.

Other References

Merck
14,9519
Harmonized Tariff Code
2930.90
TSCA
Yes

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