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J61835 Bafilomycin A1

CAS Number
88899-55-2
Synonyms

Stock No. Size Price ($) Quantity Availability
J61835-M^ 1mg 268.00
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Bafilomycin A1

MDL
MFCD06795130

Chemical Properties

Formula
C35H58O9
Formula Weight
622.83
Form
Oil or film
Storage & Sensitivity
Store at -20°C.
Solubility
Soluble in methanol, ethanol, acetone and chloroform. Insoluble in water.

Applications

Bafilomycin A1 is a specific potent inhibitor of vacuolar ATPases.It is used as an antibacterial, antifungal, antineoplastic and an immunosuppressive. It prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes and is a macrolide antibiotic and potent and selective inhibitor of vacuolar-type H+ ATPase (V-ATPase).

Notes

Store in cool place. Incompatible with strong oxidizing agents.

Literature References

Miao, Y.; Li, G.; Zhang, X.; Xu, H.; Abraham, S. N. A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion. Cell 2015, 161 (6), 1306-1319.

Lee, K. I.; Kim, M. J.; Koh, H.; Lee, J. I.; Namkoong, S.; Oh, W. K.; Park, J.The anti-hypertensive drug reserpine induces neuronal cell death through inhibition of autophagic flux. Biochem. Biophys. Res. Commun. 2015, 462 (4), 402-408.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c

Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
4730700
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
RN9781000

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