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Papain, from papaya latex, has been used to digest carotid artery smooth muscle cells. Papain is used in dissecting solutions. It is used to produce Fab fragments of antibodies. It is used for cell dissociation since it has been shown to be more effective and less damaging with certain tissues.
A. Agrawal and K. Konno. Latex: A Model for Understanding Mechanisms, Ecology, and Evolution of Plant Defense against Herbivory. Annual Review of Ecology, Evolution, and Systematics. 2009, 40, (15), 311-331.
J. R. Kimmel and E. L. Smith. Crystalline Papain, Part I. Preparation, Specificity, and Activation. Journal of Biological Chemistry. 1954, 207, (2), 515-531.
Hazard Statements: H315-H319-H334-H335
Causes skin irritation. Causes serious eye irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause respiratory irritation.
Precautionary Statements: P284-P261-P280a-P305+P351+P338-P405-P501a
Wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.