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9001-73-4 - Papain, Carica Papaya Latex - EC 3.4.22.2 - J61875 - Alfa Aesar

J61875 Papain, Carica Papaya Latex

CAS Number
9001-73-4
Synonyms
EC 3.4.22.2

Size Price ($) Quantity Availability
25mg 40.30
100mg 98.00
1g 629.00
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Papain, Carica Papaya Latex

MDL
MFCD00131791
EINECS
232-627-2

Chemical Properties

Form
Lyophilized powder, 23 kDa
Solubility
Soluble in water, insoluble in most organic solvents. 

Applications

Papain, from papaya latex, has been used to digest carotid artery smooth muscle cells. Papain is used in dissecting solutions. It is used to produce Fab fragments of antibodies. It is used for cell dissociation since it has been shown to be more effective and less damaging with certain tissues.

Notes

Activates to at least 15 units per mg protein. One unit hydrolyzes one micromole of benzoyl-L-arginine ethyl ester per minute at 25 C and pH 6.2 after activation in a solution containing 1.1 mM EDTA, 0.067 mM mercaptoethanol and 5.5 mM cysteine-HCl for 30 minutes.

Literature References

A. Agrawal and K. Konno. Latex: A Model for Understanding Mechanisms, Ecology, and Evolution of Plant Defense against Herbivory. Annual Review of Ecology, Evolution, and Systematics. 2009, 40, (15), 311-331.

J. R. Kimmel and E. L. Smith. Crystalline Papain, Part I. Preparation, Specificity, and Activation. Journal of Biological Chemistry. 1954, 207, (2), 515-531.

GHS Hazard and Precautionary Statements

Hazard Statements: H334-H315-H319-H335

May cause allergy or asthma symptoms or breathing difficulties if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P285-P261-P280-P305+P351+P338-P304+P340-P342+P311-P362-P312-P405-P501a

In case of inadequate ventilation wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,7016
Harmonized Tariff Code
3507.90
TSCA
Yes
RTECS
RU4950000

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