It is used as a small molecule IMPDH inhibitor. mycophenolic Acid is used as an immunosuppressive agent with antiviral and antitumor effects. It potently inhibits inosine monophosphate dehydrogenase, thus inhibiting de novo GTP synthesis leading to decreased RNA and DNA synthesis. It also reversibly inhibits proliferation of T and B lymphocytes and antibody formation.
Eugui et al. Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depeletion. Scand.J.Immunol. 1991, 33, (2), 161-73.
Allison et al. Mechanisms of action of mycophenolic acid. Ann.N.Y.Acad.Sci. 1993, 696, 63-87.
Hazard Statements: H302
Harmful if swallowed.
Precautionary Statements: P264-P270-P301+P312a-P330-P501a
Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.