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50679-08-8 - Terfenadine - J61936 - Alfa Aesar

J61936 Terfenadine

CAS Number
50679-08-8
Synonyms

Size Price ($) Quantity Availability
100mg 275.00
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Terfenadine

MDL
MFCD00079622
EINECS
256-710-8

Chemical Properties

Formula
C32H41NO2
Formula Weight
471.67
Form
Powder
Melting point
145-152°
Solubility
Soluble in chloroform, DMSO (100 nM), ethanol (25 nM), and water (0.001 g/100 ml) at 30°C.

Applications

Terfenadine has been used to study the role of histamine in itch related to proteinase-activated receptors (PARs) in mice. Terfenadine has also been used to block histamine receptor type 1 to study the pathogenesis of 2,4-dinitrobenzene sulfonic acid (DNBS)-induced ulcerative colitis in rats.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Avoid formation of dust and aerosols. Keep away from strong oxidizing agents

Literature References

Crumb. Loratadine blockade of K+ channels in human heart: comparison with terfenadine under physiological conditions. J.Pharmacol.Exp.Ther. 2000, 292, (1), 261-4.

Zunkler et al. Mechanism of terfenadine block of ATP-sensitive K+ channels. Br.J.Pharmacol. 2000, 130, (7), 1571-4.

GHS Hazard and Precautionary Statements

Hazard Statements: H303

May be harmful if swallowed.

Precautionary Statements: P312

Call a POISON CENTER or doctor/physician if you feel unwell.

Other References

Merck
14,9163
Harmonized Tariff Code
2933.39
TSCA
No
RTECS
TM4969000

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