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Terfenadine has been used to study the role of histamine in itch related to proteinase-activated receptors (PARs) in mice. Terfenadine has also been used to block histamine receptor type 1 to study the pathogenesis of 2,4-dinitrobenzene sulfonic acid (DNBS)-induced ulcerative colitis in rats.
Crumb. Loratadine blockade of K+ channels in human heart: comparison with terfenadine under physiological conditions. J.Pharmacol.Exp.Ther. 2000, 292, (1), 261-4.
Zunkler et al. Mechanism of terfenadine block of ATP-sensitive K+ channels. Br.J.Pharmacol. 2000, 130, (7), 1571-4.
Hazard Statements: H303
May be harmful if swallowed.
Precautionary Statements: P312a