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J61954 Benzotropine methanesulfonate

CAS Number
132-17-2
Synonyms
Benztropine mesylate
Benztropine hydrobromidum

Stock No. Size Price ($) Quantity Availability
J61954-MC 100mg 10.90
J61954-03 1g 21.30
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Benzotropine methanesulfonate

MDL
MFCD00074784
EINECS
205-048-8

Chemical Properties

Formula
C21H25NO.CH3SO3H
Formula Weight
403.54
Form
Solid
Melting point
135°
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in water (81 mg/ml at 25°C), DMSO (50 mg/ml at 25°C), ethanol (81 mg/ml at 25°C), and ether (very slightly).

Applications

Benzotropine methanesulfonate is used to treat the symptoms of Parkinson?s disease and is currently in clincial trials for chronic back pain. It shows anti-muscarinic effects comparable to Atropine, and also demonstrates competitive anti-nicotinic action at the nAChR (nicotinic acetylcholine receptor).

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agents. Store at 4°C.

Literature References

Heidi Bisgaard; M Andreas B Larsen; Sonia Mazier; Thijs Beuming; Amy Hauck Newman; Harel Weinstein; Lei Shi; Claus J Loland; Ulrik Gether. The binding sites for benztropines and dopamine in the dopamine transporter overlap. Neuropharmacology. 2011, 60, (1), 182-190.

José A G Agúndez; Elena García-Martín; Hortensia Alonso-Navarro; Félix Javier Jiménez-Jiménez. Anti-Parkinson's disease drugs and pharmacogenetic considerations. Expert Opinion on Drug Metabolism and Toxicology. 2013, 9, (7), 859-874.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H311-H330

Toxic if swallowed. Toxic in contact with skin. Fatal if inhaled.

Precautionary Statements: P260-P264b-P270-P271-P280-P284-P301+P310-P302+P352-P304+P340-P310-P312-P330-P361-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. Wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. Remove/Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,1121
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2933.99
TSCA
No
RTECS
YM3150000

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