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305-03-3 - Chlorambucil, 98% - 4-(4-[Bis(2-chloroethyl)amino]phenyl)butyric acid - J61964 - Alfa Aesar

J61964 Chlorambucil, 98%

CAS Number
305-03-3
Synonyms
4-(4-[Bis(2-chloroethyl)amino]phenyl)butyric acid

Size Price ($) Quantity Availability
500mg 50.40
1g 91.60
5g 420.00
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Chlorambucil, 98%

MDL
MFCD00021783
EINECS
206-162-0

Chemical Properties

Formula
C14H19Cl2NO2
Formula Weight
304.21
Form
Powder
Melting point
66-67°
Solubility
Soluble in ether, and ethanol:chloroform:acetone (3:5:4) (warm). Insoluble in water.

Applications

Chlorambucil is an anti-cancer drug that alkylates DNA and induces apoptosis. It can be covalently coupled to monoclonal anticarcinombryonic antigen.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.

Literature References

 Soler M.; González-Bártulos M.; Figueras E.; Ribas X.; Costas M.; Massaguer A.; Planas M.;Feliu L. Enzyme-triggered delivery of chlorambucil from conjugates based on the cell-penetrating peptide BP16. Org Biomol Chem. 2015, 13, (5), 1470-80.

Wang X.; Li J.; Xu C.; Li Y.; Gong T.; Sun X.; Fu Y.; He Q.; Zhang Z. Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil. Bioconjug Chem. 2014, 25, (11), 2046-54.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H315-H319-H350-H335

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause cancer. May cause respiratory irritation.

Precautionary Statements: P201-P261-P301+P310a-P305+P351+P338-P405-P501a

Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. IF SWALLOWED: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,2073
Beilstein
999011
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2922.49
TSCA
No
RTECS
ES7525000

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