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Chlorambucil is an anti-cancer drug that alkylates DNA and induces apoptosis. It can be covalently coupled to monoclonal anticarcinombryonic antigen.
Soler M.; González-Bártulos M.; Figueras E.; Ribas X.; Costas M.; Massaguer A.; Planas M.;Feliu L. Enzyme-triggered delivery of chlorambucil from conjugates based on the cell-penetrating peptide BP16. Org Biomol Chem. 2015, 13, (5), 1470-80.
Wang X.; Li J.; Xu C.; Li Y.; Gong T.; Sun X.; Fu Y.; He Q.; Zhang Z. Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil. Bioconjug Chem. 2014, 25, (11), 2046-54.
Hazard Statements: H301-H315-H319-H350-H335
Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause cancer. May cause respiratory irritation.
Precautionary Statements: P201-P261-P301+P310a-P305+P351+P338-P405-P501a
Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.