Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

93479-97-1 - Glimepiride - J62032 - Alfa Aesar

J62032 Glimepiride

CAS Number
93479-97-1
Synonyms

Size Price ($) Quantity Availability
100mg 124.00
1g 345.05
Add to Cart Add to Quote Request View Item

Glimepiride

MDL
MFCD00878417

Chemical Properties

Formula
C24H34N4O5S
Formula Weight
490.62
Form
Powder
Melting point
212-215°
Solubility
Soluble in DMSO

Applications

Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway. Furthermore, Glimepiride enhances intrinsic peroxisome proliferator-activated receptor γ activity. Glimepiride also increases protein expression of glucose transports 1 and 4, and is a potent KIR channel blocker. Potent Kir6 (KATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac Kir6 channels with an IC50 of 6.8 nM.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literature References

Lawrence et al. Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sacrolemmal KATP channels. Br.J.Pharmacol. 2002, 136, (5), 746-52.

SE Nissen.; SJ Nicholls.; K Wolski.; R Nesto.; S Kupfer. Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: the periscope randomized controlled . JAMA. 2008, 299, (13), 1561-1573.

Other References

Merck
14,4440
Harmonized Tariff Code
2935.00
TSCA
No
RTECS
UX9363950

Recommended

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware