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Cholic acid sodium salt is a bio-surfactant which can be used as a reducing reagent in aqueous solution. It is also used as a non-denaturing detergent used for extraction of membrane proteins. Sodium cholate hydrate has been used in a study to assess the effect of phospholipid formulation and surfactants on the dermal delivery of hydrophilic drugs from elastic liposomes. It has also been used in a study to investigate the elastic deformable vesicles, transfersomes, for transdermal drug delivery.
Kevin B Ita et. al. Dermal delivery of selected hydrophilic drugs from elastic liposomes: effect of phospholipid formulation and surfactants. Journal of Pharmacy and Pharmacology. 2007, 59, (9), 1215-1222.
Yan Qiao et. al. Controllable synthesis of water-soluble gold nanoparticles and their applications in electrocatalysis and surface-enhanced Raman scattering. Langmuir. 2011, 27, (17), 11090-11097.