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It induces cell differentiation and apoptosis of some cancer cell types and inhibiting carcinogenesis. It plays an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. It acts as a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR) that act as transcription factors to regulate the growth and differentiation of normal and malignant cells.
Arora A.; Willhite CA.; Liebler DC. Interactions of beta-carotene and cigarette smoke in human bronchial epithelial cells. Carcinogenesis. 2001, 22, (8), 1173-1178.
French AL.; Kirstein LM.; Massad LS.; et al. Association of vitamin A deficiency with cervical squamous intraepithelial lesions in human immunodeficiency virus-infected women. J Infect Dis. 2000, 182, (4), 1084-1089.
Hazard Statements: H302-H315-H319-H361d-H500
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. Suspected of damaging the unborn child. May form combustible dust concentrations in air
Precautionary Statements: P201-P202-P264b-P270-P280-P280i-P301+P312-P302+P352-P305+P351+P338-P308+P313-P330-P332+P313-P337+P313-P362-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Wear protective gloves/protective clothing/eye protection/face protection. Wear eye/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Rinse mouth. If skin irritation occurs: If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant