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5-Fluorouridine exhibits anticancer activity. It is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs. It is an active metabolite of Doxifluridine.
Ales Obrdlik; Piergiorgio Percipalle. The F-actin severing protein cofilin-1 is required for RNA polymerase II transcription elongation. Nucleus (Austin, Tex. : Print).2011, 2, (1), 72-79.
P V Sahasrabudhe; R T Pon, W H Gmeiner. Effects of site-specific substitution of 5-fluorouridine on the stabilities of duplex DNA and RNA. Nucleic Acids Research.1995, 23, (19), 3916-3921.
Hazard Statements: H341
Suspected of causing genetic defects.
Precautionary Statements: P201-P280-P202-P308+P313-P405-P501a
Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.