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32004-67-4 - Sulindac sulfide - J62104 - Alfa Aesar

J62104 Sulindac sulfide

CAS Number
32004-67-4
Synonyms

Size Price ($) Quantity Availability
100mg 245.00
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Sulindac sulfide

MDL
MFCD00869764
EINECS
250-892-2

Chemical Properties

Formula
C20H17FO2S
Formula Weight
340.41
Form
Powder
Melting point
189-191°
Solubility
Soluble in DMSO

Applications

It is also shown to inhibit growth and induce apoptosis in human prostate cancer cells through a COX-1 and COX-2 independent mechanism. Sulindac sulfide is an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells, and reduces tumor burden in adenomatous polyposis patients. Human endothelial cells, HMEC-1 were treated with Sulindac sulfide and the effect on cell survival was studies by MTT assay.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literature References

S Flis et. al. Antiangiogenic effect of sulindac sulfide could be secondary to induction of apoptosis and cell cycle arrest. Anticancer Research. 2006, 26, ( 4B), 3033-3041.

M T Taylor et. al. Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells. Cancer Research. 2000, 60, ( 23), 6607-6610.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H334-H317-H361

Harmful if swallowed. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. Suspected of damaging fertility or the unborn child.

Precautionary Statements: P284-P201-P261-P280-P405-P501a

Wear respiratory protection. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2930.90
TSCA
No
RTECS
NK8236000

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