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J62164 Amlodipine besylate, 98+%

CAS Number
111470-99-6
Synonyms

Stock No. Size Price ($) Quantity Availability
J62164-03 1g 104.00
J62164-06 5g 201.00
J62164-14 25g 515.00
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Amlodipine besylate, 98+%

MDL
MFCD00887594

Chemical Properties

Formula
C20H25ClN2O5.C6H5SO3H
Formula Weight
567.05
Form
Solid
Melting point
195-204°
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in DMSO (?20 mg/mL), water (10 mM), chloroform, ethanol (?14 mg/mL), and methanol.

Applications

Amlodipine besylate is used as a dihydropyridine calcium channel blocker. It is also used as an antianginal and antihypertensive. Amlodipine besylate also displays vasoprotective effects in cardiovascular disease and inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM). Amlodipine besylate has been shown to inhibit proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literature References

Burges et al. Calcium channel blocking properties of amlodipine in vascular smooth muscle and cardiac muscle in vitro: evidence for voltage modulation of vascular dihydropyridine receptors. J.Cardiovasc.Pharmacol. 1987, 9, ( 1), 110-9.

Yoshida et al. Antiproliferative effect of Ca2+ channel blockers on human epidermoid carcinoma A431 cells. Eur.J.Pharmacol. 2003, 472, ( 1-2), 23-31.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,491
Harmonized Tariff Code
2933.39
TSCA
No
RTECS
US7967700

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