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70-18-8 - L-Glutathione, reduced, 98+% - gamma-L-Glutamyl-L-cysteinylglycine - GSH - J62166 - Alfa Aesar

J62166 L-Glutathione, reduced, 98+%

CAS Number
70-18-8
Synonyms
gamma-L-Glutamyl-L-cysteinylglycine
GSH

Size Price ($) Quantity Availability
5g 38.11
25g 90.64
100g 241.02
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L-Glutathione, reduced, 98+%

MDL
MFCD00065939
EINECS
200-725-4

Chemical Properties

Formula
C10H17N3O6S
Formula Weight
307.33
Form
Crystalline powder
Melting point
ca 193° dec.
Solubility
Soluble in water, dimethyl formamide, ethanol, phosphate buffered saline, diluted alcohol, liquid ammonia and dimethyl sulfoxide.

Applications

A tripeptide used for the reductive cleavage of disulfide bonds L-Glutathione is used in the treatment of lung diseases for patients who are HIV positive. It protects the cancerous cells by conferring resistance to chemotherapeutic drugs. It is involved in many aspects of metabolism including transport of g-glutanyl amino acids and reductive cleavage of disulfide bonds. As an antioxidant, it prevents damage to important cellular components that arise due to reactive oxygen species like free radicals and peroxide. It is also used to decrease the concentrations of inflammatory cytokines (IL-6, IL-18) as well as involved in increasing the level of serum Ca<sup>2+</sup> ions. It is also used in white wine production.

Notes

Store in cool place. Incompatible with strong oxidizing agents.

Literature References

Deheshi, S.; Dabiri, B.; Fan, S.; Tsang, M.; Rintoul, G. L. Changes in mitochondrial morphology induced by calcium or rotenone in primary astrocytes occur predominantly through ros-mediated remodeling. J. Neurochem. 2015, 133 (5), 684-699.

Li, X.; Zheng, L.; Wang, Y.; Zhang, N.; Lou, Y.; Xiao, T.; Liu, J. A novel electrocatalyst with high sensitivity in detecting glutathione reduced by 2-hydroxypropyl- β-cyclodextrin enveloped 10-methylphenothiazine. RSC Adv. 2015, 5 (88), 71749-71755.

Other References

Merck
14,4475
Beilstein
1729812
Harmonized Tariff Code
2930.90
TSCA
Yes
RTECS
MC0556000

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