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J62182 DL-Aminoglutethimide, 99%

CAS Number
125-84-8
Synonyms
(±)-3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione

Stock No. Size Price ($) Quantity Availability
J62182-03 1g 31.70
J62182-06 5g 83.80
J62182-14 25g 303.00
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DL-Aminoglutethimide, 99%

MDL
MFCD00010122
EINECS
204-756-4

Chemical Properties

Formula
C13H16N2O2
Formula Weight
232.28
Form
Powder
Melting point
152-154°
Storage & Sensitivity
Keep Cold.
Solubility
Soluble in water (2 mg/ml at 20°C), methanol (50 mg/ml), ethanol (7 mg/ml at 25°C), DMSO (20 mg/ml at 25°C), and chloroform.

Applications

Aminoglutethimide is used to decrease the production of sex hormones and suppress the growth of tumors that need sex hormones to grow. It blocks the production of steroids derived from cholesterol and is clinically used in the treatment of Cushing's syndrome and metastatic breast cancer. It is also a drug of abuse by body builders.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literature References

Imming P.; Sinning C.; Meyer A. Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov.2006, 5, (10), 821-34.

Siraki AG.; Bonini MG.; Jiang J.; Ehrenshaft M.; Mason RP. Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. Chem Res Toxicol.2007, 20, (7), 1038-45.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c

Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,440
Harmonized Tariff Code
2925.19
TSCA
No
RTECS
MA4026950

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