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125-84-8 - DL-Aminoglutethimide, 99% - (±)-3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione - J62182 - Alfa Aesar

J62182 DL-Aminoglutethimide, 99%

CAS Number
125-84-8
Synonyms
(±)-3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione

Size Price ($) Quantity Availability
1g 29.70
5g 79.30
25g 297.00
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DL-Aminoglutethimide, 99%

MDL
MFCD00010122
EINECS
204-756-4

Chemical Properties

Formula
C13H16N2O2
Formula Weight
232.28
Form
Powder
Melting point
152-154°
Solubility
Soluble in water (2 mg/ml at 20°C), methanol (50 mg/ml), ethanol (7 mg/ml at 25°C), DMSO (20 mg/ml at 25°C), and chloroform.

Applications

Aminoglutethimide is used to decrease the production of sex hormones and suppress the growth of tumors that need sex hormones to grow. It blocks the production of steroids derived from cholesterol and is clinically used in the treatment of Cushing's syndrome and metastatic breast cancer. It is also a drug of abuse by body builders.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literature References

Imming P.; Sinning C.; Meyer A. Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov.2006, 5, (10), 821-34.

Siraki AG.; Bonini MG.; Jiang J.; Ehrenshaft M.; Mason RP. Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. Chem Res Toxicol.2007, 20, (7), 1038-45.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,440
Harmonized Tariff Code
2925.19
TSCA
No
RTECS
MA4026950

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