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17230-88-5 - Danazol - 17beta-Hydroxy-2,4,17a-pregnadien-20-yno[2,3-d]isoxazole - 2,4,17a-Pregnadien-20-yno[2,3-d]isoxazol-17-ol - J62200 - Alfa Aesar

J62200 Danazol

CAS Number
17230-88-5
Synonyms
17beta-Hydroxy-2,4,17a-pregnadien-20-yno[2,3-d]isoxazole
2,4,17a-Pregnadien-20-yno[2,3-d]isoxazol-17-ol

Size Price ($) Quantity Availability
100mg 48.20
500mg 196.00
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Danazol

MDL
MFCD00056838
EINECS
241-270-1

Chemical Properties

Formula
C22H27NO2
Formula Weight
337.46
Form
Powder
Melting point
218-220°
Solubility
Partly soluble in water. Soluble in chloroform (25 mg/ml), acetone, acetonitrile, and ethanol. 17beta-Hydroxy-2,4,17a-pregnadien-20-yno[2,3-d]isoxazole and 2,4,17a-Pregnadien-20-yno[2,3-d]isoxazol-17-ol are the synonym of this compound.

Applications

Danazol is a synthetic gonadotropin inhibitor which has a preventive effect on estrogen -related endometrial carcinogenesis in mice. Danazol therapy has also shown regression of established mammary carcinoma in rats. This medication is used in women to treat pelvic pain and infertility due to a certain uterus disorder (endometriosis) and also to treat breast pain/tenderness/nodules due to a certain breast condition (fibrocystic breast disease). It is also used in both men and women to prevent swelling of the abdomen/arms/legs/face/airway due to a certain congenital disease

Notes

Store at room temperature. Incompatible with oxidizing agents.

Literature References

Gary G. Liversidge.; Kenneth C. Cundy. Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs.Int. J. Pharm. 1995, 125 (1),91-97 .

GHS Hazard and Precautionary Statements

Hazard Statements: H312-H332-H361

Harmful in contact with skin. Harmful if inhaled. Suspected of damaging fertility or the unborn child.

Precautionary Statements: P260-P201-P280h-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/clothing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,2812
Harmonized Tariff Code
2937.29
TSCA
No
RTECS
TU4157070

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