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11089-65-9 - Tunicamycin, 95% - J62217 - Alfa Aesar

J62217 Tunicamycin, 95%

CAS Number
11089-65-9
Synonyms

Size Price ($) Quantity Availability
10mg 171.00
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Tunicamycin, 95%

MDL
MFCD00065709

Chemical Properties

Formula
C39H64N4O16
Formula Weight
844.95
Form
Powder
Sensitivity
Moisture & Light Sensitive
Solubility
Soluble in methanol, ethanol, DMSO, or DMF

Applications

Tunicamycin has been widely used in the study of glycoprotein synthesis in various biological systems. During protein glycosylation, tunicamycin is noted to be an inhibitor of the transfer of saccharide moieties to dolichol during dolichol-linked glycoprotein synthesis. Dose-dependent inhibition of DNA synthesis may be related to the alteration of glycoproteins, which thereby affects the transport of thymidine into cells. Additionally, tunicamycin has been reported to prevent cell cycle progression in primary cultures of rat glial cells, as well as inhibit lipid-mediated protein glycosylation in chick or mouse fibroblasts in a dose-dependent manner.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C Light sensitive. Moisture sensitive.

Literature References

Ding et al. Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J.Biol.Chem. 2007, 282, (7), 4702-10.

Duriez et al. The hepatitis B virus precore protein is retrotransported from endoplasmic reticulum (ER) to cytosol through the ER-associated pathway. J.Biol.Chem. 2008, 283, (47), 32352-60.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H330-H373

Fatal if swallowed. Fatal if inhaled. May cause damage to organs through prolonged or repeated exposure.

Precautionary Statements: P301+P310a-P304+P340-P320-P330-P405-P501a

IF SWALLOWED: Immediately call a POISON CENTER/doctor IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,9819
Beilstein
6888090
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
YO7980200

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