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5300-03-8 - 9-cis-Retinoic acid - J62219 - Alfa Aesar

J62219 9-cis-Retinoic acid

CAS Number
5300-03-8
Synonyms

Size Price ($) Quantity Availability
5mg 176.02
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9-cis-Retinoic acid

MDL
MFCD00270072

Chemical Properties

Formula
C20H28O2
Formula Weight
300.44
Form
Powder
Melting point
178-180°
Sensitivity
Moisture & Light Sensitive
Solubility
Soluble in chloroform (50 mg/ml), DMSO (~25 mg/ml), ethanol (25 mg/ml), and acetone (25 mg/ml). Insoluble in water.

Applications

9-cis-Retinoic acid is a vitamin A analog that inhibits cell proliferation and induces cell differentiation. 9-cis-Retinoic acid is an inhibitor of Cox-2 and an activator of RAR α, RAR β, RAR γ and RXR.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents.

Literature References

SA Kliewer.; K Umesono.; DJ Noonan.; RA Heyman. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature. 1992, 358, 771 - 774.

RA Heyman.; DJ Mangelsdorf.; JA Dyck.; RB Stein. 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell. 1992, 68, (2), 397-406.

GHS Hazard and Precautionary Statements

Hazard Statements: H360-H315-H319-H335

May damage fertility or the unborn child. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P201-P261-P280-P281-P305+P351+P338-P304+P340-P362-P312-P405-P501a

Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,249
Harmonized Tariff Code
2916.20
TSCA
No
RTECS
VH6450000

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