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J62229 Deoxyribonuclease I, bovine pancreas

CAS Number
DNase I

Stock No. Size Price ($) Quantity Availability
J62229-MB 25mg 56.10
J62229-MC 100mg 145.00
J62229-03 1g 1150.00
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Deoxyribonuclease I, bovine pancreas


Chemical Properties

Lyophilized powder, 31 kDa
Storage & Sensitivity
Keep Cold.
It is soluble in 0.15 M NaCl.


Deoxyribonuclease I is used for the removal of DNA from protein samples. DNAse I is used to nick DNA as a first step to incorporate labeled bases into DNA. The enzyme from Sigma has been used during the isolation of plasma membrane vesicles from Neurospora crassa cell culture.1 It has also been used along with trypsin for the preparation of single cell suspension from rat testes. Deoxyribonuclease I from bovine pancreas has been used in a study to compare several procedures for reducing RNase contamination in preparations of DNase. Deoxyribonuclease I from bovine pancreas has also been used in a study to investigate the effect of the composition of sodium dodecyl sulfate preparations on the renaturation of enzymes after polyacrylamide gel electrophoresis


Minimum 2,000 units per mg dry weight. One unit causes an increase in absorbance at 260nm of 0.001 per minute per ml at 25 degrees when acting upon highly polymerized DNA at pH 5.0

Literature References

G A Scarborough. The neurospora plasma membrane ATPase is an electrogenic pump. PNAS. 1976, 73 (5), 1485-1488.

U Lindberg. Molecular weight and amino acid composition of deoxyribonuclease I. Biochemistry. 1967, 6 (1), 335-342.

GHS Hazard and Precautionary Statements

Hazard Statements: H317-H334

May cause an allergic skin reaction. May cause allergy or asthma symptoms or breathing difficulties if inhaled.

Precautionary Statements: P272-P280g-P285-P302+P352-P304+P341-P333+P313-P342+P311-P363-P501c

Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves. In case of inadequate ventilation wear respiratory protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. If skin irritation or rash occurs: Get medical advice/attention. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

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