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Bumetanide has been observed to block the depolarization of GABA in cortical development studies. It is been used as a specific inhibitor of Na+-K+-2Cl- cotransporter NKCC1
Star, R.A., et al. Luminal disequilibrium pH and ammonia transport in outer medullary collecting duct. Am. J. Physiol. 1987, 252( 6 Pt 2), F1148-F1157.
O'Grady, S.M., et al. Characteristics and functions of Na-K-Cl cotransport in epithelial tissues. Am. J. Physiol. 1987, 253( 2 Pt 1), C177-C192.