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633-65-8 - Berberine chloride - C.I. 75160 - Natural Yellow 18 - J62311 - Alfa Aesar

J62311 Berberine chloride

CAS Number
633-65-8
Synonyms
C.I. 75160
Natural Yellow 18

Size Price ($) Quantity Availability
5g 34.71
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Berberine chloride

MDL
MFCD00011939
EINECS
211-195-9

Chemical Properties

Formula
C20H18ClNO4
Formula Weight
371.82
Form
Powder
Solubility
Soluble in dimethyl sulfoxide (74 mg/ml at 25°C), ethanol (<1 mg/ml at 25°C), water (<1 mg/ml at 25°C), and methanol.

Applications

Berberine is an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme Cox-2 (cyclooxygenase-2) which is abundantly expressed in colon cancer cells. Also inhibits c-Jun (Activator Protein 1), a transcription factor that plays a critical role in inflammation and carcinogenesis. Berberine upregulates the expression of Pgp in hepatoma cells. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs.

Notes

Store at -20°C. Incompatible with oxidizing agents. Protect from heat.

Literature References

Shrinivas K. Kulkarni.; Ashish Dhir. Possible involvement of l-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant activity of berberine chloride. Eur. J. Pharmacol. 2007, 569 (1-2),77-83 .

Other References

Beilstein
3836585
Harmonized Tariff Code
2939.99
TSCA
Yes

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