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446-86-6 - Azathioprine - 6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine - J62314 - Alfa Aesar

J62314 Azathioprine

CAS Number
446-86-6
Synonyms
6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine

Size Price ($) Quantity Availability
1g 76.10
5g 280.00
10g 534.00
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Azathioprine

MDL
MFCD00069203
EINECS
207-175-4

Chemical Properties

Formula
C9H7N7O2S
Formula Weight
277.26
Form
Crystalline powder
Solubility
Soluble in Dichloromethane and dimethyl sulfoxide.

Applications

Azathioprine is an immunosuppressive purine antimetabolite. The mechanism of action of azathioprine is as a nucleic acid synthesis inhibitor. It has shown promise in treatment of alopecia areata (autoimmune hair loss), with no difference in effectiveness between genders.

Notes

Store at -20°C. Incompatible with oxidizing agents. Protect from heat.

Literature References

W.R. Connell.; Kamm.; Ritchie.; Prof J.E. Lennard-Jones.; Dickson.; A.M. Balkwill. Long-term neoplasia risk after azathioprine treatment in inflammatory bowel disease.The Lancet. 1994, 343 (8908),1249-1252 .

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H350-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause cancer. May cause respiratory irritation.

Precautionary Statements: P201-P261-P280-P305+P351+P338-P405-P501a

Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,902
Harmonized Tariff Code
2933.59
TSCA
No
RTECS
UO8925000

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