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J62314 Azathioprine

CAS Number
446-86-6
Synonyms
6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine

Stock No. Size Price ($) Quantity Availability
J62314-03 1g 85.90
J62314-06 5g 280.00
J62314-09 10g 616.00
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Azathioprine

MDL
MFCD00069203
EINECS
207-175-4

Chemical Properties

Formula
C9H7N7O2S
Formula Weight
277.26
Form
Crystalline powder
Storage & Sensitivity
Store at -20°C.
Solubility
Soluble in Dichloromethane and dimethyl sulfoxide.

Applications

Azathioprine is an immunosuppressive purine antimetabolite. The mechanism of action of azathioprine is as a nucleic acid synthesis inhibitor. It has shown promise in treatment of alopecia areata (autoimmune hair loss), with no difference in effectiveness between genders.

Notes

Store at -20°C. Incompatible with oxidizing agents. Protect from heat.

Literature References

W.R. Connell.; Kamm.; Ritchie.; Prof J.E. Lennard-Jones.; Dickson.; A.M. Balkwill. Long-term neoplasia risk after azathioprine treatment in inflammatory bowel disease.The Lancet. 1994, 343 (8908),1249-1252 .

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335-H350

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May cause cancer.

Precautionary Statements: P201-P202-P261-P264b-P270-P271-P280i-P281-P301+P312-P302+P352-P304+P340-P305+P351+P338-P308+P313-P330-P332+P313-P337+P313-P362-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear eye/face protection. Use personal protective equipment as required. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Rinse mouth. If skin irritation occurs: If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,902
Harmonized Tariff Code
2933.59
TSCA
No
RTECS
UO8925000

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