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1393-48-2 - Thiostrepton, Streptomyces laurentii, 90+% - Bryamycin - Thiactin - J62332 - Alfa Aesar

J62332 Thiostrepton, Streptomyces laurentii, 90+%

CAS Number
1393-48-2
Synonyms
Bryamycin
Thiactin

Size Price ($) Quantity Availability
1g 168.00
5g 691.00
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Thiostrepton, Streptomyces laurentii, 90+%

MDL
MFCD00135828
EINECS
215-734-9

Chemical Properties

Formula
C72H85O18N19S5
Formula Weight
1664.89
Form
Powder
Solubility
Soluble in DMSO or chloroform

Applications

Thiostrepton exhibits antibiotic activity through blockade of ribosome turnover after an elongation step in protein synthesis by inhibiting both the dissociation of elongation factor G (EF-G) from the ribosome and the release of inorganic phosphate from EF-G following GTP hydrolysis. Thiostrepton is also described to show efficacy against cancer cell growth through downregulation of the forkhead box M1 (FOXM1) transcription factor, commonly overexpressed in many malignancies. Thiostrepton is an inhibitor of FOXM1. Thiostrepton has been used as a selectable marker for recombinant Streptomyces cultures.

Notes

Store at -20°C. Incompatible with oxidizing agents. Protect from heat.

Literature References

Ursula Mocek.; Zhaopie Zeng.; David O'Hagan.; Pei Zho.; Lai Duen G. Fan.; John M. Beale.; Heinz G. Floss. Biosynthesis of the modified peptide antibiotic thiostrepton in Streptomyces azureus and Streptomyces laurentii.J. Am. Chem. Soc. 1993, 115 (18),7992-8001 .

Takahiro Suzuki.; Tsuneo Yamane.; Shoichi Shimizu. Mass production of thiostrepton by fed-batch culture of Streptomyces laurentii with pH-stat modal feeding of multi-substrate. . 1987, 25 (6),526-531 .

Other References

Merck
14,9364
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
XN6300100

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