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Brefeldin A mediated apoptosis has been observed in human tumor cellsIt is an antibiotic used in cell culture and to inhibit protein secretion in mammalian and other eukaryotic cells by interfering with the function of the Golgi apparatus.
Wase, N.; Tu, B.; Black, P. N.; DiRusso, C. C. Phenotypic screening identifies Brefeldin A/Ascotoxin as an inducer of lipid storage in the algae Chlamydomonas reinhardtii. Algal Res. 2015, 11, 74-84.
Fuchs, M.; Fîrstner, A. trans-Hydrogenation: Application to a Concise and Scalable Synthesis of Brefeldin A. Angew. Chem. 2015, 54 (13), 3978 -3982.
Hazard Statements: H302
Harmful if swallowed.
Precautionary Statements: P260-P201-P280-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.