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beta-endorphins produce analgesia by binding to opioid receptors (particularly of the mu subtype) at both pre- and post- synaptic nerve terminals, primarily exerting their effect through presynaptic binding. In the central nervous system, beta-endorphins similarly bind mu-opioid receptors and exert their primary action at presynaptic nerve terminals. It is a potent pain suppressant.
Y Hosobuchi.; J Rossier.; FE Bloom.; R Guillemin. Stimulation of human periaqueductal gray for pain relief increases immunoreactive beta-endorphin in ventricular fluid.Science. 1979, 203 ( 4377),279-281 .
L. Grandison.; A. Guidotti. Stimulation of food intake by muscimol and beta endorphin. Neuropharmacology. 1977, 16 (1-2), 533-536.