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56092-81-0 - Ionomycin, 98% - J62448 - Alfa Aesar

J62448 Ionomycin, 98%

CAS Number
56092-81-0
Synonyms

Size Price ($) Quantity Availability
1mg 58.59
5mg 250.29
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Ionomycin, 98%

MDL
MFCD06798385

Chemical Properties

Formula
C41H72O9
Formula Weight
709.02
Form
Solution in ethanol
Solubility
Soluble to 10 mM in Ethanol and to 10 mM in DMSO.

Applications

Ionomycin free acid is a beneficial tool in research to raise intracellular calcium levels. Also this antibiotic can be used to study the calcium transport across the plasma membrane. It has been shown to induce central demyelination , inhibit adrenal bovine TREK-1 channels , and to regulate cell division of mature human B cells . It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochondrial stress and intrinsic apoptosis mechanisms. It is also used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA.

Notes

A 10mg/ml solution in ethanol

Literature References

Liu and Hermann. Characterization of ionomycin as a calcium ionophore. J.Biol.Chem.. 1978, 253, (17), 5892-4.

Kaufmann et al. Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria. J.Biol.Chem.. 1980, 255, (7), 2735-9.

GHS Hazard and Precautionary Statements

Hazard Statements: H225

Highly flammable liquid and vapour.

Precautionary Statements: P210-P280-P240-P241-P233-P242-P243-P303+P361+P353-P403+P235-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Keep container tightly closed. Use only non-sparking tools. Take precautionary measures against static discharge. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
3642126
Hazard Class
3
Packing Group
II
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
NO0600000

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