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31884-77-2 - Meclizine dihydrochloride monohydrate - J62464 - Alfa Aesar

J62464 Meclizine dihydrochloride monohydrate

CAS Number
31884-77-2
Synonyms

Size Price ($) Quantity Availability
1g 32.00
5g 150.00
10g 270.00
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Meclizine dihydrochloride monohydrate

MDL
MFCD00058199

Chemical Properties

Formula
C25H27ClN2•2HCl•H2O
Formula Weight
481.89 (463.88anhy)
Form
Powder
Melting point
210-213°
Solubility
Insoluble in water.

Applications

Antiemetic and H1-histamine receptor antagonistMeclizine dihydrochloride monohydrate acts as an antiemetic. It is also used for the prevention and treatment of nausea during pregnancy. In addition to this, it is used in radiation sickness, vomiting or dizziness associated with motion sickness. Product purchased here is only for use in Research and Development.

Notes

Incompatible with heat and oxidizing agents.

Literature References

Foo, W. Y. B.; Tay, H. Y.; Chan, E. C. Y.; Lau, A. J. Meclizine, a pregnane X receptor agonist, is a direct inhibitor and mechanism-based inactivator of human cytochrome P450 3A. Biochem. Pharmacol. 2015, 97 (3), 320-330.

Lau, A. J.; Yang, G.; Rajaraman, G.; Baucom, C. C.; Chang, T. K. H. Differential Effect of Meclizine on the Activity of Human Pregnane X Receptor and Constitutive Androstane Receptor. J. Pharmacol. Exp. Ther. 2011, 336 (3), 816-826.

GHS Hazard and Precautionary Statements

Hazard Statements: H361-H302

Suspected of damaging fertility or the unborn child. Harmful if swallowed.

Precautionary Statements: P201-P281-P264-P270-P202-P301+P312-P308+P313-P330-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. Do not handle until all safety precautions have been read and understood. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF exposed or concerned: Get medical advice/attention. Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,5777
Harmonized Tariff Code
2933.59
TSCA
Yes

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