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53123-88-9 - Rapamycin, 99+% - Sirolimus - AY-22989 - J62473 - Alfa Aesar

J62473 Rapamycin, 99+%

CAS Number
53123-88-9
Synonyms
Sirolimus
AY-22989

Size Price ($) Quantity Availability
50mg 93.73
100mg 155.53
200mg 291.49
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Rapamycin, 99+%

MDL
MFCD00867594

Chemical Properties

Formula
C51H79NO13
Formula Weight
914.17
Form
Powder
Solubility
Soluble in DMSO at 50mg/ml or methanol at 25mg/mlSoluble in alcohol, dimethyl sulfoxide and dimethyl formamide. Insoluble in water.

Applications

Blocks cytokine-mediated signal transduction pathwaysRapamycin is used to inhibit tumor growth by halting tumor cell proliferation and suppressing tumor angiogenesis. It forms a complex with FKBP12 that binds and inhibits the molecular target of rapamycin (mTOR) as well as suppresses the immune system, preventing transplant rejection.

Notes

Store at -20°. Research Use only: Not intended for animal or human diagnostic or therapeutic use.Store in a cool place.Incompatible with strong oxidizing agents.

Literature References

Hong, S.; Zhao, B.; Lombard, D. B.; Fingar, D. C.; Inoki, K. Cross-talk between sirtuin and mammalian target of rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation. J. Biol. Chem. 2014, 289 (19), 13132-13141.

Quy, P. N.; Kuma, A.; Pierre, P.; Mizushima, N. Proteasome-dependent activation of mammalian target of rapamycin complex 1 (mTORC1) is essential for autophagy suppression and muscle remodeling following denervation. J. Biol. Chem. 2013, 288 (2), 1125-1134.

Other References

Merck
14,8114
Harmonized Tariff Code
2934.99
TSCA
No
RTECS
VE6250000

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