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136632-32-1 - Calpain Inhibitor II, 95+% - N-Ac-Leu-Leu-Methioninal - ALLM - J62491 - Alfa Aesar

J62491 Calpain Inhibitor II, 95+%

CAS Number
136632-32-1
Synonyms
N-Ac-Leu-Leu-Methioninal
ALLM

Size Price ($) Quantity Availability
5mg 64.80
25mg 269.86
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Calpain Inhibitor II, 95+%

MDL
MFCD00065506

Chemical Properties

Formula
C19H35N3O4S
Formula Weight
401.60
Form
Powder
Solubility
Soluble in ethanol at 20mg/ml

Applications

ALLM (Calpain Inhibitor) is a cell-permeable, peptide aldehyde inhibitor of calpain I and calpain II. ALLM acts as a very potent inhibitor of cathepsin L and the strongest inhibitor of cathepsin B amongst the peptide aldehydes. This compound inhibits the processing of malaria aspartic hemoglobinases plasmepsins I and II in vitro. ALLM also inhibits other neutral cysteine proteases, and activation-induced programmed cell death. It restores defective immune responses in HIV+ donors. ALLM blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. ALLM also acts as a weak inhibitor of proteasome.

Notes

Store at -20°C. Incompatible with oxidizing agents. Protect from heat.

Literature References

Sonia del Cerro.; John Larson.; Michael W. Oliver.; Gary Lynch. Development of hippocampal long-term potentiation is reduced by recently introduced calpain inhibitors.Brain Research. 1990, 530 (1),91-95 .

Other References

Beilstein
7693643
Harmonized Tariff Code
2930.90
TSCA
No

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