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7689-03-4 - Camptothecin - (S)-(+)-Camptothecin - J62523 - Alfa Aesar

J62523 Camptothecin

CAS Number
7689-03-4
Synonyms
(S)-(+)-Camptothecin

Size Price ($) Quantity Availability
250mg 70.10
1g 140.00
5g 561.00
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Camptothecin

MDL
MFCD00081076

Chemical Properties

Formula
C20H16N2O4
Formula Weight
348.35
Form
Powder
Melting point
260° dec.
Solubility
Soluble in dimethyl sulfoxide, 0.1N sodium hydroxide and acetic acid. Insoluble in water.

Applications

Camptothecin is used as a cytotoxic antitumor agent that inhibits topoisomerase I.Camptothecin shows remarkable anticancer activity based on preliminary clinical trials. Its analogues are used in cancer chemotherapy. Cyclodextrin-based polymer containing camptothecin is used in the investigational anti-cancer drug study.

Notes

Store in cool place. Incompatible with strong oxidizing agents.

Literature References

Li, R.; Shu, C.; Wang, W.; Wang, X.; Li, H.; Xu, D.; Zhong, W. Encapsulation of 10-Hydroxy Camptothecin in Supramolecular Hydrogel as an Injectable Drug Delivery System. J. Pharm. Sci. 2015, 104 (7), 2266-2275.

Liu, Y. Q.; Li, W. Q.; Natschke, S. L. M.; Qian, K.; Yang, L.; Zhu, G. X.; Wu, X. B.; Chen, A. L.; Zhang, S. Y.; Nan, X.; Lee, K. H. Perspectives on Biologically Active Camptothecin Derivatives. Med Res Rev 2015, 35 (4), 753-789.

GHS Hazard and Precautionary Statements

Hazard Statements: H301

Toxic if swallowed.

Precautionary Statements: P264-P270-P301+P310a-P321-P405-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Immediately call a POISON CENTER/doctor Specific treatment (see label). Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,1735
Beilstein
631069
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2939.80
TSCA
No
RTECS
UQ492000

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