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76721-89-6 - DL-Thiorphan - DL-3-Mercapto-2-benzylpropanoylglycine - J62557 - Alfa Aesar

J62557 DL-Thiorphan

CAS Number
76721-89-6
Synonyms
DL-3-Mercapto-2-benzylpropanoylglycine

Size Price ($) Quantity Availability
25mg 311.00
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DL-Thiorphan

MDL
MFCD00058435

Chemical Properties

Formula
C12H15NOS
Formula Weight
253.32
Form
Powder
Melting point
135-137°
Solubility
Soluble in ethanol at 50mg/ml

Applications

Thiorphan has the ability to block the degradation of the luteinizing hormone releasing hormone (LHRH). At higher concentrations, (14 ?M) this compound has been shown to inhibit the activity of angiotensin-converting enzyme (ACE). Neprilysin is overexpressed in many forms of cancer and may play a role in protecting against Alzheimer’s disease.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong acids, strong bases.

Literature References

Amantini C et al. Thiorphan-induced survival and proliferation of rat thymocytes by activation of Akt/survivin pathway and inhibition of caspase-3 activity. J Pharmacol Exp Ther . 2008, 327, (1), 215-25.

Medja F et al. Thiorphan, a neutral endopeptidase inhibitor used for diarrhoea, is neuroprotective in newborn mice. Brain . 2006, 129, (pt 12), 3209-23.

GHS Hazard and Precautionary Statements

Precautionary Statements: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
4872101
Harmonized Tariff Code
2930.90
TSCA
No
RTECS
MC0596440

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