It is a highly potent H1 histamine receptor antagonist (Kd = 310 pM) and tricyclic antidepressant that inhibits the reuptake of serotonin and norepinephrine and acts as an antagonist at histamine, serotonin, adrenergic, and muscarinic receptors with Ki values in the nanomolar range. Also binds to the H4 histamine receptor (pKi = 6.79). Used clinically to treat anxiety and depression.
Tran VT, et al. [3H]doxepin interactions with histamine H1-receptors and other sites in guinea pig and rat brain homogenates.Eur J Pharmacol.,1981,70(4), 501-9.
Luchins DJ. Review of clinical and animal studies comparing the cardiovascular effects of doxepin and other tricyclic antidepressants.Am J Psychiatry.,1983,140(8), 1006-9.
Hazard Statements: H301-H361
Toxic if swallowed. Suspected of damaging fertility or the unborn child.
Precautionary Statements: P201-P280-P301+P310a-P308+P313-P405-P501a
Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.