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1229-29-4 - Doxepin hydrochloride - 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepine hydrochloride - J62579 - Alfa Aesar

J62579 Doxepin hydrochloride

CAS Number
1229-29-4
Synonyms
11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepine hydrochloride

Size Price ($) Quantity Availability
1g 32.60
5g 125.00
25g 560.00
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Doxepin hydrochloride

MDL
MFCD00079135
EINECS
214-966-8

Chemical Properties

Formula
C19H21NO•HCl
Formula Weight
315.84
Form
Powder
Melting point
187-189°
Solubility
Soluble in water (100 mM), chloroform (1:2), alcohol (1:1), methanol, and DMSO.

Applications

It is a highly potent H1 histamine receptor antagonist (Kd = 310 pM) and tricyclic antidepressant that inhibits the reuptake of serotonin and norepinephrine and acts as an antagonist at histamine, serotonin, adrenergic, and muscarinic receptors with Ki values in the nanomolar range. Also binds to the H4 histamine receptor (pKi = 6.79). Used clinically to treat anxiety and depression.

Notes

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

Tran VT, et al. [3H]doxepin interactions with histamine H1-receptors and other sites in guinea pig and rat brain homogenates.Eur J Pharmacol.,1981,70(4), 501-9.

Luchins DJ. Review of clinical and animal studies comparing the cardiovascular effects of doxepin and other tricyclic antidepressants.Am J Psychiatry.,1983,140(8), 1006-9.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H361

Toxic if swallowed. Suspected of damaging fertility or the unborn child.

Precautionary Statements: P201-P281-P264-P270-P301+P310-P308+P313-P321-P330-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF exposed or concerned: Get medical advice/attention. Specific treatment (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,3435
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2932.99
TSCA
No
RTECS
HQ4375000

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