It is most often used to study the role of SR-3. Studies suggest the blockade of SR-3 with may ameliorate beta-amyloid protein-induced neurotoxicity by interfering with the increase of Ca2+, and then by inhibiting glutamate release, generation of reactive oxygen species and caspase-3 activity. It is also used in the study of dopamine elevation in rats due to cocaine and amphetamine consumption.
Fozard JR, et al. MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors.Naunyn Schmiedebergs Arch Pharmacol.,1984,326(1), 36-44.
Kankaanpää A, et al. 5-HT3 receptor antagonist MDL 72222 dose-dependently attenuates cocaine- and amphetamine-induced elevations of extracellular dopamine in the nucleus accumbens and the dorsal striatum.Pharmacol Toxicol.,1996,78(5), 317-21.