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J62583 3-Tropanyl-3,5-dichlorobenzoate, 99+%

CAS Number
40796-97-2
Synonyms
MDL-72222
Bemesetron

Stock No. Size Price ($) Quantity Availability
J62583-MF 50mg 205.00
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3-Tropanyl-3,5-dichlorobenzoate, 99+%

MDL
MFCD00865533

Chemical Properties

Formula
C15H17Cl2NO2
Formula Weight
314.21
Form
Powder
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble to 100 mM in DMSO. Insoluble in water. Sparingly soluble in chloroform, and ethanol.

Applications

It is most often used to study the role of SR-3. Studies suggest the blockade of SR-3 with may ameliorate beta-amyloid protein-induced neurotoxicity by interfering with the increase of Ca2+, and then by inhibiting glutamate release, generation of reactive oxygen species and caspase-3 activity. It is also used in the study of dopamine elevation in rats due to cocaine and amphetamine consumption.

Notes

Soluble to 100 mM in DMSO. Insoluble in water.

Literature References

Fozard JR, et al. MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors.Naunyn Schmiedebergs Arch Pharmacol.,1984,326(1), 36-44.

Kankaanpää A, et al. 5-HT3 receptor antagonist MDL 72222 dose-dependently attenuates cocaine- and amphetamine-induced elevations of extracellular dopamine in the nucleus accumbens and the dorsal striatum.Pharmacol Toxicol.,1996,78(5), 317-21.

Other References

Harmonized Tariff Code
2939.80
TSCA
No
RTECS
DG7580000

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