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298-46-4 - Carbamazepine, 98% - 5H-Dibenz[b,f]azepine-5-carboxamide - J62590 - Alfa Aesar

J62590 Carbamazepine, 98%

CAS Number
298-46-4
Synonyms
5H-Dibenz[b,f]azepine-5-carboxamide

Size Price ($) Quantity Availability
25g 95.00
100g 289.00
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Carbamazepine, 98%

MDL
MFCD00005073
EINECS
206-062-7

Chemical Properties

Formula
C15H12N2O
Formula Weight
236.27
Form
Powder
Melting point
189-192°
Solubility
Soluble in ethanol, acetone, propylene glycol, chloroform, dimethyl sulfoxide, methanol, dimethyl fluoride,ethylene glycol and monoethyl ether. Slightly soluble in glacial acetic acid. Insoluble in water.

Applications

Carbamazepine is used as cytochrome P450 3A4 inducing anti-epileptic drug and ligand for the GABA-A receptor benzodiazepine modulatory site. Carbamazepine is typically used for the treatment of seizure disorders and neuropathic pain. It is associated with other medications and used to treat schizophrenia as well as a second line agent in bipolar disorders.

Notes

Store in cool place. Incompatible with strong oxidizing agents.

Literature References

Tolbert, D.; Cloyd, J.; Biton, V.; Bekersky, I.; Walzer, M.; Wesche, D.; Drummond, R.; Lee, D. Bioequivalence of oral and intravenous carbamazepine formulations in adult patients with epilepsy. Epilepsia. 2015, 56 (6), 915-923.

Shokry, E.; Villanelli, F.; Malvagia, S.; Rosati, A.; Forni, G.; Funghini, S.; Ombrone, D.; Bona, M. D.; Guerrini, R.; Marca, G. L. Therapeutic drug monitoring of carbamazepine and its metabolite in children from dried blood spots using liquid chromatography and tandem mass spectrometry. J. Pharm. Biomed. Anal. 2015, 109, 164-170.

GHS Hazard and Precautionary Statements

Hazard Statements: H334-H317-H302

May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. Harmful if swallowed.

Precautionary Statements: P285-P261-P280-P342+P311-P301+P312-P363-P304+P341-P321-P333+P313-P501a

In case of inadequate ventilation wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment (see label). If skin irritation or rash occurs: Get medical advice/attention. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,1781
Harmonized Tariff Code
2933.99
TSCA
No
RTECS
HN8225000

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