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19130-96-2 - (+)-1-Deoxynojirimycin - 1,5-Dideoxy-1,5-imino-D-glucitol - (2R,3R,4R,5S)-2-(Hydroxymethyl)-3,4,5-piperidinetriol - J62602 - Alfa Aesar

J62602 (+)-1-Deoxynojirimycin

CAS Number
19130-96-2
Synonyms
1,5-Dideoxy-1,5-imino-D-glucitol
(2R,3R,4R,5S)-2-(Hydroxymethyl)-3,4,5-piperidinetriol

Size Price ($) Quantity Availability
100mg 500.00
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(+)-1-Deoxynojirimycin

MDL
MFCD00063474

Chemical Properties

Formula
C6H13NO4
Formula Weight
163.17
Form
Powder
Melting point
195-196°
Solubility
Soluble in water, dimethyl sulfoxide and methanol.

Applications

An alpha-glucosidase inhibitor. Interferes with normal processing of N-linked glycoproteins.(+)-1-Deoxynojirimycin acts as an inhibitor of alfa-glucosidase I and II and maltase-glucoamylase. It also inhibits mammalian glucosidase, intestinal and lysosmal, beta-glucosidase from sweet almonds, pancreatic alfa-amylase and amyloglucosidase. Further, it serves as a enzyme enhancer for the treatment of Fabry and Pompe disease.

Notes

Incompatible with strong acids and strong bases.

Literature References

Liu, C.; Xiang, W.; Yu, Y.; Shi, Z. Q.; Huang, X. Z.; Xu, L. Comparative analysis of 1-deoxynojirimycin contribution degree to alpha-glucosidase inhibitory activity and physiological distribution in Morus alba L. Ind. Crops Prod. 2015, 70, 309-315.

Park, S. H.; Kim, J. Y.; Kim, J. S.; Jung, C.; Song, D. K.; Ham, W. H. 1,3-Oxazine as a chiral building block used in the total synthesis of (+)-1-deoxynojirimycin and (2R,5R)-dihydroxymethyl-(3R,4R)-dihydroxypyrrolidine. Tetrahedron: Asymmetry 2015, 26 (12-13), 657-661.

Other References

Merck
14,2905
Harmonized Tariff Code
2933.39
TSCA
No
RTECS
TN4350300

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