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15307-79-6 - Diclofenac sodium salt - 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt - Sodium 2-(2,6-dichloroanilino)phenylacetate - J62609 - Alfa Aesar

J62609 Diclofenac sodium salt

CAS Number
15307-79-6
Synonyms
2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt
Sodium 2-(2,6-dichloroanilino)phenylacetate

Size Price ($) Quantity Availability
5g 27.40
25g 61.80
100g 193.00
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Diclofenac sodium salt

MDL
MFCD00082251
EINECS
239-346-4

Chemical Properties

Formula
C14H10Cl2NNaO2
Formula Weight
318.14
Form
Powder
Melting point
283-285°
Solubility
Soluble in water to 50mg/ml.

Applications

Oxidation of diclofenac sodium produces the metabolite 4'-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literature References

Barnett, J., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim. Biophys. Acta. 1994, 1209, (1), 130-9.

Laneuville, O., et al. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J. Pharmacol. Exp. Ther. 1994, 271, (2), 927-34.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H361

Toxic if swallowed. Suspected of damaging fertility or the unborn child.

Precautionary Statements: P201-P281-P264-P270-P301+P310-P308+P313-P321-P330-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF exposed or concerned: Get medical advice/attention. Specific treatment (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,3081
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2922.49
TSCA
No
RTECS
AG6330000

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