Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

546-06-5 - Conessine, 97% - Neriine - Roquessine - J62617 - Alfa Aesar

J62617 Conessine, 97%

CAS Number
546-06-5
Synonyms
Neriine
Roquessine

Size Price ($) Quantity Availability
100mg 77.15
250mg 154.50
Add to Cart Add to Quote Request View Item

Conessine, 97%

MDL
MFCD00016752
EINECS
208-897-2

Chemical Properties

Formula
C24H40N2
Formula Weight
356.59
Form
Powder
Melting point
125-127°
Solubility
Soluble to 50 mM in ethanol and to 50 mM in DMSO with gentle warming.

Applications

It have been used in traditional herbal medicine as a treatment for amoebic dysentery. In a radioligand-based high-throughput screen, conessine demonstrated high affinity for both rat and human histamine H3 receptors (Kis = 5.2 and 24.5 nM, respectively) and high selectivity against histamine receptors H1, H2, and H4.1 Though conessine potently blocks H3 agonist-stimulated GTPγS binding in cell- and tissue-based functional assays and efficiently crosses the blood-brain barrier, it has a poor rate of CNS clearance.

Notes

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

Zhao, C, et al. The alkaloid conessine and analogues as potent histamine H3 receptor antagonists. Med Chem.,2008,515423-5430.

Siddiqui BS, et al. Antimicrobial activity of the methanolic bark extract of Holarrhena pubescens (Buch. Ham), its fractions and the pure compound conessine.Natural product research.,2012,26(11), 987-992.

Other References

Merck
14,2497
Harmonized Tariff Code
2939.99
TSCA
No

Recommended

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware