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HEPES is common buffer for biological sciences, particularly used in cell culture to maintain physiological pH. It acts a buffering component, which is used in the preparation of buffers. It is described as one of the best all-purpose buffers available for use in biological research.
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Yang, H. N.; Park, J. S.; Jeon, S. Y.; Park, K. H. Carboxymethylcellulose (CMC) formed nanogels with branched poly (ethyleneimine)(bPEI) for inhibition of cytotoxicity in human MSCs as a gene delivery vehicles. Carbohydr. Polym. 2015, 122, 265-275.