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70458-96-7 - Norfloxacin - Baccidal - Sebercim - J62652 - Alfa Aesar

J62652 Norfloxacin

CAS Number
70458-96-7
Synonyms
Baccidal
Sebercim

Size Price ($) Quantity Availability
1g 16.30
5g 45.80
25g 138.00
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Norfloxacin

MDL
MFCD00079532
EINECS
274-614-4

Chemical Properties

Formula
C16H18FN3O3
Formula Weight
319.33
Form
Powder
Melting point
220-221°
Solubility
Soluble in acetic acid. Also soluble in acetone or cloroform. Slightly soluble in water

Applications

It finds it application as a fluorinated quinolone antibacterial. It is clinically used to treat urinary tract infections and prostatitis. In neutrophils from cirrhotic subjects, norfloxacin increases expression of IL-10 and heme oxygenase 1 (HO-1) and decreases expression of pro-inflammatory cytokines. Additionally, when complexed with gold(III), norfloxacin binds DNA and inhibits cellular proliferation in several cancer cell lines.

Notes

Store away from heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Keep it refrigerated.

Literature References

Gouvea LR, et al. A typical fluoroquinolone gold(III) chelates as potential anticancer agents: relevance of DNA and protein interactions for their mechanism of action.Eur J Med Chem.,2012,5567-73.

Gómez-Hurtado I, et al. Interleukin-10-mediated heme oxygenase 1-induced underlying mechanism in inflammatory down-regulation by norfloxacin in cirrhosis.Hepatology.,2011,53(3), 935-44.

Other References

Merck
14,6700
Harmonized Tariff Code
2933.59
TSCA
No
RTECS
VB5005000

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