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78415-72-2 - Milrinone, 98+% - Corotrope - Milrila - J62659 - Alfa Aesar

J62659 Milrinone, 98+%

CAS Number
78415-72-2
Synonyms
Corotrope
Milrila

Size Price ($) Quantity Availability
10mg 108.00
50mg 444.60
100mg 767.70
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Milrinone, 98+%

MDL
MFCD00133539
EINECS
278-903-6

Chemical Properties

Formula
C12H9N3O
Formula Weight
211.22
Form
Powder
Melting point
264°
Solubility
Soluble in DMSO. Insoluble in water.

Applications

It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure. Milrinone inhibits the action of phosphodiesterase-3 preventing degradation of cAMP. The corresponding increase in cAMP levels leads to increased activation of protein kinase A. It is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity.

Notes

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

Narimatsu E, et al. Milrinone, a phosphodiesterase III inhibitor, antagonizes the neuromuscular blocking effect of a non-depolarizing muscle relaxant in vitro.Res. Commun. Mol. Pathol. Pharmacol.,1999,104(2), 219-228.

Cheung P, et al. Milrinone, a selective phosphodiesterase 3 inhibitor, stimulates lipolysis, endogenous glucose production, and insulin secretion.Metabolism: clinical and experimental.,2003,52(11), 1496-1500.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H311-H331

Fatal if swallowed. Toxic in contact with skin. Toxic if inhaled.

Precautionary Statements: P261-P280-P301+P310-P361-P304+P340-P311-P312-P363-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. Remove/Take off immediately all contaminated clothing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician. Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,6197
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2933.79
TSCA
No
RTECS
DW1762000

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