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64490-92-2 - Tolmetin sodium salt dihydrate, 98+% - J62663 - Alfa Aesar

J62663 Tolmetin sodium salt dihydrate, 98+%

CAS Number
64490-92-2
Synonyms

Size Price ($) Quantity Availability
1g 20.90
5g 83.69
25g 418.47
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Tolmetin sodium salt dihydrate, 98+%

MDL
MFCD00150761
EINECS
252-687-3

Chemical Properties

Formula
C15H14NNaO3•2H2O
Formula Weight
315.30 (279.27anhy)
Form
Powder
Solubility
Soluble in water

Applications

Tolmetin Sodium is an anti-inflammatory, antirheumatic agent. It can inhibit aldo-keto reductases (e.g., IC50 = 2.39 µM for human aldose reductase), a family of enzymes that catalyze the NADPH-dependent reduction of carbonyl groups in a number of important steroid, metabolic, and prostanoid molecules. It is a beta-adrenergic blocker.

Notes

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

Warner, T.D, et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis.Proc Natl Acad Sci USA.,1999,967563-7568.

Zheng, X, et al. The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase.FEBS Lett.,2012,586(1), 55-59.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315

Harmful if swallowed. Causes skin irritation.

Precautionary Statements: P280-P264-P270-P362-P301+P312-P321-P332+P313-P302+P352-P330-P501a

Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. IF ON SKIN: Wash with plenty of soap and water. Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,9518
Harmonized Tariff Code
2933.99
TSCA
No
RTECS
UX9280000

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