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Tolmetin Sodium is an anti-inflammatory, antirheumatic agent. It can inhibit aldo-keto reductases (e.g., IC50 = 2.39 µM for human aldose reductase), a family of enzymes that catalyze the NADPH-dependent reduction of carbonyl groups in a number of important steroid, metabolic, and prostanoid molecules. It is a beta-adrenergic blocker.
Warner, T.D, et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis.Proc Natl Acad Sci USA.,1999,967563-7568.
Zheng, X, et al. The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase.FEBS Lett.,2012,586(1), 55-59.
Hazard Statements: H302-H315
Harmful if swallowed. Causes skin irritation.
Precautionary Statements: P280g-P264-P301+P312a-P321-P332+P313-P501a
Wear protective gloves. Wash thoroughly after handling. IF SWALLOWED: Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. Dispose of contents/container in accordance with local/regional/national/international regulations.