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G418 disulfate is an aminoglycoside that is toxic to bacteria, yeast, protozoans and helminths. It prevents protein synthesis by blocking the elongation step in prokaryotic and eukaryotic ribosomes. It is used as a selection agent for G418 resistant bacteria or fungi after transformation.
Lemke, K.; Förster, T.; Römer, R.; Quade, M.; Wiedemeier, S.; Grodrian, A.; Gastrock, G. A modular segmented-flow platform for 3D cell cultivation. J. Biotechnol. 2015, 205, 59-69.
Meta, A.; Hirashima, M.; Imamura, T.; Kawamura, R.; Yano, K.; Uehara, K.; Nakashima, T. High-yield preparation of recombinant human α-thrombin for therapeutic use. J. Biosci. Bioeng. 2015, 120 (4), 432-437.
Hazard Statements: H334-H317
May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction.
Precautionary Statements: P284-P261-P280g-P342+P311a-P363-P501a
Wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves. If experiencing respiratory symptoms: Call a POISON CENTER/doctor. Wash contaminated clothing before reuse. Dispose of contents/container in accordance with local/regional/national/international regulations.