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TES has potential for a variety of biological applications. In many culture media that require metal cations, many buffers cannot be used due to chelation or precipitation (citrate or phosphate, for example). TES was found to be beneficial in a study of succinate oxidation. TES is a suitable buffer for epidermal cell growth at pH 7.4 - 7.9 where additional buffering capacity is required. It is also useful in cell culture media formulations.
Good, N E., et al. Hydrogen ion buffers for biological research. Biochemistry. 1966, 5, (2), 467-77.
AE Kelly.; HD Ou.; R Withers. Low-conductivity buffers for high-sensitivity NMR measurements. J. Am. Chem. Soc. 2002, 124, (40), 12013-12019.