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J62734 Paclitaxel, 99.5+%

CAS Number
33069-62-4
Synonyms

Stock No. Size Price ($) Quantity Availability
J62734-MC 100mg 105.00
J62734-ME 500mg 304.00
J62734-03 1g 572.00
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Paclitaxel, 99.5+%

MDL
MFCD00869953

Chemical Properties

Formula
C47H51NO14
Formula Weight
853.91
Form
Crystalline solid
Melting point
213° dec.
Storage & Sensitivity
Store at -20°C.
Solubility
Soluble in DMSO (200mg/ml) or ethanol (40mg/ml). Soluble in dimethylsulfoxide, methanol, ethanol, acetonitrile, cremophor and dimehtylsulfamide. Sparingly soluble in aqueous buffer.

Applications

Promotes assembly and inhibits disassembly of microtubules (anti-cancer agent)Paclitaxel is widely used in chemotherapeutic compound. It is used to treat certain types of cancer such as ovarian cancer, breast cancer, lung cancer and pancreatic cancer among others. It interferes with the growth of cancer cells and slows down their growth and spread in the body. It is also used to treat AIDS-related Kaposi's sarcoma.

Notes

Isolated from Taxus brevifoliaIncompatible with oxidizing agents.

Literature References

England, C. G.; Miller, M. C.; Kuttan, A.; Trent, J. O.; Frieboes, H. B. Release kinetics of paclitaxel and cisplatin from two and three layered gold nanoparticles. Eur. J. Pharm. Biopharm. 2015, 92, 120-129.

Liu, Y.; Ran, R.; Chen, J.; Kuang, Q.; Tang, J.; Mei, L.; Zhang, Q.; Gao, H.; Zhang, Z.; He, Q. (2014). Paclitaxel loaded liposomes decorated with a multifunctional tandem peptide for glioma targeting. Biomaterials 2014, 35 (17), 4835-4847.

GHS Hazard and Precautionary Statements

Hazard Statements: H318

Causes serious eye damage.

Precautionary Statements: P280-P305+P351+P338-P310

Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.

Other References

Merck
14,6982
Beilstein
1420457
Harmonized Tariff Code
2932.99
TSCA
No
RTECS
DA8340700

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