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33069-62-4 - Paclitaxel, 99.5+% - J62734 - Alfa Aesar

J62734 Paclitaxel, 99.5+%

CAS Number
33069-62-4
Synonyms

Size Price ($) Quantity Availability
100mg 98.30
500mg 289.00
1g 544.00
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Paclitaxel, 99.5+%

MDL
MFCD00869953

Chemical Properties

Formula
C47H51NO14
Formula Weight
853.91
Form
Crystalline solid
Melting point
213° dec.
Solubility
Soluble in DMSO (200mg/ml) or ethanol (40mg/ml). Soluble in dimethylsulfoxide, methanol, ethanol, acetonitrile, cremophor and dimehtylsulfamide. Sparingly soluble in aqueous buffer.

Applications

Promotes assembly and inhibits disassembly of microtubules (anti-cancer agent)Paclitaxel is widely used in chemotherapeutic compound. It is used to treat certain types of cancer such as ovarian cancer, breast cancer, lung cancer and pancreatic cancer among others. It interferes with the growth of cancer cells and slows down their growth and spread in the body. It is also used to treat AIDS-related Kaposi's sarcoma.

Notes

Isolated from Taxus brevifoliaIncompatible with oxidizing agents.

Literature References

England, C. G.; Miller, M. C.; Kuttan, A.; Trent, J. O.; Frieboes, H. B. Release kinetics of paclitaxel and cisplatin from two and three layered gold nanoparticles. Eur. J. Pharm. Biopharm. 2015, 92, 120-129.

Liu, Y.; Ran, R.; Chen, J.; Kuang, Q.; Tang, J.; Mei, L.; Zhang, Q.; Gao, H.; Zhang, Z.; He, Q. (2014). Paclitaxel loaded liposomes decorated with a multifunctional tandem peptide for glioma targeting. Biomaterials 2014, 35 (17), 4835-4847.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H312-H332-H315-H318-H334-H317-H341-H361-H335

Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes skin irritation. Causes serious eye damage. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. Suspected of causing genetic defects. Suspected of damaging fertility or the unborn child. May cause respiratory irritation.

Precautionary Statements: P284-P201-P261-P305+P351+P338-P405-P501a

Wear respiratory protection. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,6982
Beilstein
1420457
Harmonized Tariff Code
2932.99
TSCA
No
RTECS
DA8340700

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