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L-type calcium channel blocker; induces apoptosis in human glioblastoma cells.Nifedipine is a dihydropyridine calcium channel blocker used as L-type calcium channel blocker, antianginal and an antihypertensive . It induces apoptosis in human glioblastoma cells. It is used as a coronary vasodilator in the treatment of cardiac and circulatory disorders. Further, it is used in high-altitude medicine to treat high altitude pulmonary edema, hypertension and chronic stable angina. In addition, it is frequently used as a tocolytic agent.
Weerapol, Y.; Limmatvapirat, S.; Jansakul, C.; Takeuchi, H.; Sriamornsak, P. Enhanced dissolution and oral bioavailability of nifedipine by spontaneous emulsifying powders: Effect of solid carriers and dietary state. Eur. J. Pharm. Biopharm. 2015, 91, 25-34.
Miao, X. N.; Siu, K. L.; Cai, H. Nifedipine attenuation of abdominal aortic aneurysm in hypertensive and non-hypertensive mice: Mechanisms and implications. J. Mol. Cell. Cardiol. 2015, 87, 152-159.
Hazard Statements: H302
Harmful if swallowed.
Precautionary Statements: P264b-P270-P301+P312-P330-P501c
Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. Dispose of contents/ container to an approved waste disposal plant