Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

139481-59-7 - Candesartan, 98% - J62818 - Alfa Aesar

J62818 Candesartan, 98%

CAS Number
139481-59-7
Synonyms

Size Price ($) Quantity Availability
100mg 53.90
1g 245.00
Add to Cart Add to Quote Request View Item

Candesartan, 98%

MDL
MFCD00081076

Chemical Properties

Formula
C24H20N6O3
Formula Weight
440.45
Form
Powder
Melting point
183-185°
Solubility
Soluble in ethyl acetate, methanol, water (<1 mg/ml at 25°C), DMSO (88 mg/ml at 25°C), and ethanol (1 mg/ml at 25°C).

Applications

Candesartan is a selective AT1 (angiotensin II receptor 1) antagonist. Antagonism of angiotensin receptors inhibits vasoconstriction and the production of aldosterone, leading to a decrease in water and sodium concentration in blood plasma. Exhibits antihypertensive effects in animal models. Used in treatment of congestive heart failure, as antihypertensive. Candesartan does not affect cell viability or proliferation but increases the expression of VEGF and interleukin-8 in the cultured medium of KU-19-19 cells. Candesartan (0.1 nM) could reduce the maximal contractile response to angiostensin II by approximately 50%.

Notes

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

Kaur N, et al. Design, synthesis, and evaluation of 5-sulfamoyl benzimidazole derivatives as novel angiotensin II receptor antagonists.Bioorg Med Chem.,2008,16(24), 10210-5.

Nishikawa K, et al. Candesartan cilexetil: a review of its preclinical pharmacology.J Hum Hypertens.,1997,29-17.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H312-H332-H315-H319-H335

Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,1739
Harmonized Tariff Code
2939.80
TSCA
No
RTECS
DD6671000

Recommended

  • H26038

    alpha-p-Xylenesulfonyl chloride, 97%
  • L12361

    4-(4-Ethylphenyl)-3-thiosemicarbazide, 98+%
  • H60477

    3-(4-Bromophenyl)-4-(3,4-dimethoxyphenyl)-5-methyl-4H-1,2,4-triazole, 97%
  • H27650

    4',5-Dihydroxyflavone, 95%
  • L01563

    2,4-Dichlorobenzeneboronic acid, 98+%

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware