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51481-61-9 - Cimetidine, 98+% - 1-Cyano-3-methyl-2-[2-(5-methyl-4-imidazolylmethylthio)ethyl]guanidine - SKF-92334 - J62825 - Alfa Aesar

J62825 Cimetidine, 98+%

CAS Number
51481-61-9
Synonyms
1-Cyano-3-methyl-2-[2-(5-methyl-4-imidazolylmethylthio)ethyl]guanidine
SKF-92334

Size Price ($) Quantity Availability
5g 80.55
10g 101.00
25g 175.20
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Cimetidine, 98+%

MDL
MFCD00133296
EINECS
257-232-2

Chemical Properties

Formula
C10H16N6S
Formula Weight
252.34
Form
Powder
Melting point
139-144°
Solubility
Soluble to 50 mM in water and to 100 mM in DMSO, solubility in HCl (almost transparency).

Applications

Widely used H2 histamine antagonist which has more recently been described as an inverse agonist. Also a potent I1 imidazoline binding site ligand. It displays antitumor and immunomodulatory activity. Cimetidine competitively inhibits histamine binding to histamine H2 receptors, and suppresses the growth of several tumors, including gastrointestinal cancer. This compound is an anti-angiogenic agent and is an activator of Nischarin. Competitive histamine H2-receptor antagonist which inhibits gastric acid secretion and reduces pepsin output

Notes

Store away from heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

Yasui-Furukori N, et al. Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics.Clinical pharmacology and therapeutics.,2005,77(1), 17-23.

Yoshizawa F, et al. Time course of leucine-induced 4E-BP1 and S6K1 phosphorylation in the liver and skeletal muscle of rats.Journal of clinical pharmacology.,1981,21(2), 87-91.

GHS Hazard and Precautionary Statements

Hazard Statements: H360-H303

May damage fertility or the unborn child. May be harmful if swallowed.

Precautionary Statements: P201-P281-P202-P312-P308+P313-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Do not handle until all safety precautions have been read and understood. Call a POISON CENTER or doctor/physician if you feel unwell. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,2279
Harmonized Tariff Code
2933.29
TSCA
No
RTECS
MF0035500

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