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It is employed as Na+ channel blocker, local anesthetic and cAMP production inhibitor. It acts as a surfactant molecule possessing both hydrophilic and lipophilic properties, adrenergic antagonist, EC 126.96.36.199 (cholinesterase) inhibitor and EC 188.8.131.52 (Ca(2+)-transporting ATPase) inhibitor.
Viscusi ER, et al. The safety of liposome bupivacaine, a novel local analgesic formulation.Clinical pharmacology and therapeutics.,2014,30(2), 102-110.
Hu D, et al. Pharmacokinetic profile of liposome bupivacaine injection following a single administration at the surgical site.Clinical drug investigation.,2013,33(2), 109-115.
Hazard Statements: H300-H310-H330
Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled.
Precautionary Statements: P260-P262-P264b-P270-P271-P280-P284-P301+P310-P302+P350-P304+P340-P310-P330-P361-P363-P501c
Do not breathe dust/fume/gas/mist/vapours/spray. Do not get in eyes, on skin, or on clothing. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. Wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Gently wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Rinse mouth. Remove/Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant